UNCARINE C
- CAS NO.:5629-60-7
- Empirical Formula: C21H24N2O4
- Molecular Weight: 368.43
- MDL number: MFCD03788764
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-24 17:20:48
What is UNCARINE C?
Description
Isolated from Uncaria pteropoda, this alkaloid is probably stereoisomeric withMitraphylline (q.v.). It forms colourless plates when crystallized from MeOH and has [α]29DJ 9 - 102.5° (c 1.0, CHC13). The ultraviolet spectrum in MeOH has an absorption maximum at 246 mp. with a shoulder at 280 mp.. A crystalline picrate, m.p. 143-6°C; [α]D - 9.6° (c 0.5, EtOH) and a methiodide, m.p. 209-211°C after softening at 204°C; [α]D - 149° (c 0.53, EtOH) have been prepared. A solution of the alkaloid in pyridine forms an equilibrium mixture with 70 per cent isopteropodine when heated.
The Uses of UNCARINE C
Uncarine C is a compound extracted from Uncaria tomentosa leaves. The compounds extracted from these leaves have exhibited immunomodulating, antiinflammatory and anti-cancer activity, attributed to the presence of tetra/pentacyclic oxindole alkaloids.
Definition
ChEBI: Uncarine C is a member of indolizines.
References
Yeoh, Chan, Morsingh., Tetrahedron Lett., 931 (1966)
Chan, Morsingh, Yeoh., 1. Chem. Soc., C, 2245 (1966)
Stereochemistry:
Shamma et al., 1. Amer. Chem. Soc., 89, 1739, 2799 (1967)
Properties of UNCARINE C
Melting point: | 217-219℃ |
Density | 1.33±0.1 g/cm3 (20 ºC 760 Torr) |
Safety information for UNCARINE C
Computed Descriptors for UNCARINE C
New Products
Tubulysin E Tubulysin A 2,2-diethoxyethanethioamide Tubulysin F Tubulysin D 4,4-DIFLUOROCYCLOHEXANAMINE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE tetrahydro-4-methyl-2H-pyran Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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