U-74389G

Synonym(s):21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate salt

CAS NO.：153190-29-5
Empirical Formula: C41H54N6O6
Molecular Weight: 726.9
MDL number: MFCD01074991
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is U-74389G?

Description

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

The Uses of U-74389G

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.

What are the applications of Application

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation

References

1) Braughler et al. (1987) Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation; J. Biol. Chem., 262 10438 2) Campo et al. (1996) Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation; J. Pharmacol. Exp. Ther., 277 333 3) Perna et al. (1996) Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G; Pharmacol. Res., 34 25

Properties of U-74389G

storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	ethanol: soluble20 mg/mL, clear, light yellow
form	White solid.
color	White
Sensitive	Hygroscopic
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.