TRIS(DIMETHYLAMINO)METHANE

CAS NO.：5762-56-1
Empirical Formula: C7H19N3
Molecular Weight: 145.25
MDL number: MFCD00008322
EINECS: 227-284-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is TRIS(DIMETHYLAMINO)METHANE?

Chemical properties

Clear colorless to slightly yellow liquid

The Uses of TRIS(DIMETHYLAMINO)METHANE

Tris(dimethylamino)methane was used:

to prepare the phosphoramidite derivative of the new nucleoside analog
as reagent for the introduction of the dimethylaminoethylidene group
in ring-opening (RO) polymerization of lactide

The Uses of TRIS(DIMETHYLAMINO)METHANE

Reagent for the introduction of the dimethylaminoethylidene group.1 General review;2 RO polymerization of lactide.3

The Uses of TRIS(DIMETHYLAMINO)METHANE

N,N,N'',N'',N'''',N''''-Hexamethylmethanetriamine, can be used in the synthesis of the phosphoramidite derivative of the new nucleoside analog. It can also be used as reagent for the introduction of the dimethylaminoethylidene group.

General Description

NMR spectra and their temperature-dependence has been reported for tris(dimethylamino)methane. Tris(dimethylamino)methane reacts with crowded α-(o-nitrophenyl) ketone to yield tetrahydroquinoline derivative.

Purification Methods

Dry it over KOH and distil it through a Vigreux column (p 11) at water pump vacuum. Store it in the absence of CO2. [Bredereck et al. Chem Ber 101 1885 1968 and Angew Chem, Int Ed Engl 5 132 1966.]

Properties of TRIS(DIMETHYLAMINO)METHANE

Boiling point:	42-43 °C/12 mmHg (lit.)
Density	0.838 g/mL at 20 °C (lit.)
refractive index	n20/D 1.436(lit.)
Flash point:	4 °F
storage temp.	2-8°C
form	Liquid
pka	6.50±0.38(Predicted)
color	Clear colorless to slightly yellow
BRN	1901162

Safety information for TRIS(DIMETHYLAMINO)METHANE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05
GHS Hazard Statements	H225:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.