TRIPALMITIN

Synonym(s):1,2,3-Propanetriol tris(hexadecanoate);Glycerol tripalmitate;Glyceryl tripalmitate;TG(16:0/16:0/16:0);Tripalmitin

CAS NO.：555-44-2
Empirical Formula: C51H98O6
Molecular Weight: 807.32
MDL number: MFCD00008995
EINECS: 209-098-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:22

What is TRIPALMITIN?

Description

1,2,3-Tripalmitoyl glycerol is a triacylglycerol that contains palmitic acid at the sn-1, sn-2, and sn-3 positions and has been found in palm oil. It inhibits glucose-stimulated insulin secretion and reduces viability of INS1 cells in a concentration-dependent manner. Myocardial levels of 1,2,3-tripalmitoyl glycerol are elevated by greater than 5-fold in a rat model of diabetes induced by streptozotocin . 1,2,3-Tripalmitoyl glycerol has been used to form the lipid matrices of etoposide-incorporated nanoparticles. Formulations containing 1,2,3-tripalmitoyl glycerol have been used in cosmetic products as thickening and skin-conditioning agents.

Chemical properties

White, crystalline powder. Soluble in ether and chloroform; insoluble in water. Combustible.

The Uses of TRIPALMITIN

Tripalmitin is a triglyceride derived from Palmitic Acid (P144500), a common fatty acid found in plants and animals. Tripalmitin is used in the preparation of solid lipid particles for oral delivery of drugs.

The Uses of TRIPALMITIN

Soap, leather dressing.

The Uses of TRIPALMITIN

Glyceryl tripalmitate has been used as a reference standard

for the generation of calibration curve generation for the quantification of lipids from Azospirillum brasilense
for the quantification of silk worm embryos and extraembryonic yolk lipids using thin layer chromatography
for the quantification of triacylglycerol in Neochloris minuta microalgal cells

What are the applications of Application

Tripalmitoylglycerol is A triglyceride used in the preparation of solid lipid particles

Definition

ChEBI: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by palmitic (hexadecanoic) acid.

General Description

SRM 1595_cert SRM 1595 _SDS

Biochem/physiol Actions

Glyceryl tripalmitate is a carrier molecule for effective drug delivery and is used solid lipid nanoparticle formulations.

Purification Methods

Crystallise it from acetone, diethyl ether or EtOH. It exists in an -form (m 56.0o), a ’-form (m 63.5o) and a -form (m 65.5o). [Beilstein 2 H 373, 2 I 167, 2 II 340, 2 III 971.]

Properties of TRIPALMITIN

Melting point:	66-68 °C
Boiling point:	bp 310-320°
Density	0.8752 g/cm³ (70 ºC)
refractive index	nD80 1.43807
storage temp.	-20°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Hexanes (Very Slightly), Metha
form	Fine Crystalline Powder
color	White to almost white
Merck	14,9736
BRN	1811188
CAS DataBase Reference	555-44-2(CAS DataBase Reference)
EPA Substance Registry System	Tripalmitin (555-44-2)

Safety information for TRIPALMITIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.