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HomeProduct name listTrioctylphosphine oxide

Trioctylphosphine oxide

Synonym(s):(Oct)3PO;Thorium ionophore I;TOPO;Trioctylphosphinoxide

  • CAS NO.:78-50-2
  • Empirical Formula: C24H51OP
  • Molecular Weight: 386.63
  • MDL number: MFCD00002083
  • EINECS: 201-121-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
Trioctylphosphine oxide Structural

What is Trioctylphosphine oxide?

Chemical properties

white crystalline powder

The Uses of Trioctylphosphine oxide

Trioctylphosphine oxide (TOPO) is most commonly used as the solvent due to its high boiling point and chemical stability, and its ability to prevent particle aggregation via coordination to the NP surface. trioctylphosphine oxide is a frequently used surfactant, starts to decompose at around 425°C.
The industrial applications of trioctylphosphine oxide, make use of its complexing powers with metals and with hydrogen donor organic compounds. Commercial uses as a solvent extraction reagent are in the recovery of uranium from wet process phosphoric acid and in the recovery of byproduct acetic acid and furfural generated during sulphite wood pulping.
TOPO is a widely used chemical compound in nanocrystal synthesis, for the removal of heavy metals, and the removal of toxins in waste water. TOPO is often used as a ligand stabilizer for colloids in traditional thermal decomposition synthetic techniques.
trioctylphosphine oxide became a nearly irreplaceable solvent (mp 51-52°C) for high-temperature preparation of various type of nanocomposites. TOPO has a very high boiling point (411°C) which is an important prerequisite for the homogeneous nucleation and good crystallinity of the nanoparticles.

The Uses of Trioctylphosphine oxide

Tri-n-octylphosphine oxide is a solvent used in the extraction of metals, especially uranium, zirconium and hafnium. It is also used as an auxiliary reagent in the solvent extraction of metals. It is also used to extract hydrogen bonding organic compounds. Further, it is useful as a capping ligand for the production of quantum dots, such as those consisting of cadmium selenide.

The Uses of Trioctylphosphine oxide

Catalyst in:

  • Preparation of tetradentate planar-chiral hydroxy-substituted ferrocenecarboxaldimine Schiff base ligands
  • Reactions of allyl esters with hydrosilanes
  • Asymmetric cyanosilylation of aldehydes
  • Preparation of chlorothiol formates from thiols and phosgene

What are the applications of Application

Trioctylphosphine oxide is a capping ligand for quantum dots to stabilize nanoparticles in organic solutions

General Description

Visit our Sensor Applications portal to learn more.

Flammability and Explosibility

Non flammable

Purification Methods

Mason, McCarty and Peppard [J Inorg Nuclear Chem 24 967 1962] stirred a 0.1M solution in *benzene with an equal volume of 6M HCl at 40o in a sealed flask for 48hours, then washed the *benzene solution successively with water (twice), 5% aqueous Na2CO3 (three times) and water (six times). The *benzene and water were then evaporated under reduced pressure at room temperature. Zingaro and White [J Inorg Nucl Chem 12 315 1960] treated a pet ether solution with aqueous KMnO4 (to oxidise any phosphinous acids to phosphinic acids), then with sodium oxalate, H2SO4 and HCl (to remove any manganese compounds). The pet ether solution was slurried with activated alumina (to remove phosphinic acids), filtered, evaporated and the residue was recrystallised from pet ether or cyclohexane at -20o. It can also be recrystallised from EtOH. [Beilstein 4 IV 3466.]

Properties of Trioctylphosphine oxide

Melting point: 50-52 °C(lit.)
Boiling point: 201-202 °C2 mm Hg(lit.)
Density  0,88 g/cm3
vapor pressure  0.004Pa at 50℃
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  <1g/l
form  Crystalline Powder, Crystals or Flakes
color  White to slightly yellow
Water Solubility  Insoluble
BRN  1796648
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 78-50-2(CAS DataBase Reference)
EPA Substance Registry System Phosphine oxide, trioctyl- (78-50-2)

Safety information for Trioctylphosphine oxide

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

Computed Descriptors for Trioctylphosphine oxide

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