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HomeProduct name listTributylphosphine

Tributylphosphine

Synonym(s):NSC 91700;P(n-Bu)3;TBP;Tributylphosphine

  • CAS NO.:998-40-3
  • Empirical Formula: C12H27P
  • Molecular Weight: 202.32
  • MDL number: MFCD00009462
  • EINECS: 213-651-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-25 16:21:11
Tributylphosphine Structural

What is Tributylphosphine?

Chemical properties

Clear liquid

The Uses of Tributylphosphine

Tributylphosphine is usually used as catalyst for Domino reactions of activated conjugated dienes with β,γ-unsaturated-α-ketoesters, [3+2]-Cycloadditions,Umpolung addition reactions,Reductive carbonylation, Allylation reactions.

The Uses of Tributylphosphine

Tributylphosphine
To a solution of the bromide (1.2 g, 4.7 mmol) in dry DMF (36 mL) degassed with N2 was added Pd(PPh3)4 (270 mg, 0.23 mmol) and the stannane (1.85 g, 5.6 mmol). The mixture was flushed with N2 for 5 min, then stirred at 80 C overnight. After cooling, the mixture was partitioned between EtOAc and brine. The org layer was washed with brine (2x), dried, and concentrated to give 3.5 g of a yellow oil. The material was purified by Prep LC (80 g silica, 5-10% EtOAc/heptane) to provide the product as a colorless oil. [900 mg, 88%]

The Uses of Tributylphosphine

1,4-addition catalyst; used with disulfides for the thioetherification of alcohols; acylation catalyst; used to prepare active esters.

The Uses of Tributylphosphine

suzuki reaction

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 2493, 1984 DOI: 10.1016/S0040-4039(01)81213-2

General Description

Tributylphosphane is a colorless to yellowish liquid with a strong garlic-like odor. Tributylphosphane is insoluble in water. Tributylphosphane is liable to heat and ignite spontaneously in air. If involved in a fire phosphine gas, a highly flammable and toxic gas, will evolve. Tributylphosphane is irritating to mucous membranes.

Air & Water Reactions

Highly flammable. May ignite on contact with air or moist air. Insoluble in water.

Reactivity Profile

Organophosphates, such as Tributylphosphane, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

Fire will produce irritating, corrosive and/or toxic gases. Inhalation of decomposition products may cause severe injury or death. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May ignite on contact with moist air or moisture. May burn rapidly with flare-burning effect. Some react vigorously or explosively on contact with water. Some may decompose explosively when heated or involved in a fire. May re-ignite after fire is extinguished. Runoff may create fire or explosion hazard. Containers may explode when heated.

Purification Methods

Fractionally distil it under reduced pressure in an inert atmosphere (N2) through an 8inch gauze-packed column (b 110-111o/10mm) and redistil it in a vacuum, then seal it in thin glass ampoules. It is easily oxidised by air to tri-n-butylphosphine oxide, b 293-296o/745mm. It has a characteristic odour, it is soluble in EtOH, Et2O, and *C6H6 but is insoluble in H2O and less easily oxidised by air than the lower molecular weight phosphines. It forms complexes, e.g. with CS2 (1:1) m 65.5o (from EtOH). [Davies & Jones J Chem Soc 33 1929, Chernick & Skinner J Chem Soc 1401 1956, Beilstein 4 IV 3436.]

Properties of Tributylphosphine

Melting point: -65 °C
Boiling point: 150 °C50 mm Hg(lit.)
Density  0.81 g/mL at 25 °C(lit.)
vapor density  9 (vs air)
vapor pressure  1.9Pa at 20℃
refractive index  n20/D 1.462(lit.)
Flash point: 99 °F
storage temp.  2-8°C
form  liquid
appearance Colorless oily liquid
color  Clear colorless to pale yellow
Specific Gravity 0.820 (20/4℃)
Water Solubility  insoluble
Sensitive  Moisture Sensitive/Air Sensitive
BRN  1738261
Stability: Stable, but pyrophoric - spontaneously inflammable in air. Incompatible with oxidizing agents. Moisture sensitive.
CAS DataBase Reference 998-40-3(CAS DataBase Reference)
NIST Chemistry Reference Phosphine, tributyl-(998-40-3)
EPA Substance Registry System Phosphine, tributyl- (998-40-3)

Safety information for Tributylphosphine

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H251:Self-heating substances and mixtures
H302:Acute toxicity,oral
H314:Skin corrosion/irritation
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P235:Keep cool.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Tributylphosphine

InChIKey TUQOTMZNTHZOKS-UHFFFAOYSA-N

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