trimetozine
- CAS NO.:635-41-6
- Empirical Formula: C14H19NO5
- Molecular Weight: 281.3
- MDL number: MFCD00023351
- EINECS: 211-236-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:12
What is trimetozine?
Originator
Opalene,Theraplix,France,1966
The Uses of trimetozine
A sedative with mild tranquilizing effects. Trimetozine has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine.
The Uses of trimetozine
antiurolithic, depigmentation, radiation protectant
The Uses of trimetozine
A sedative with mild tranquilizing effects. It has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine.
Definition
ChEBI: 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone is a member of morpholines.
Manufacturing Process
46 g 3,4,5-trimethoxybenzoyl chloride are dissolved in 300 ml anhydrous benzene and 25 g triethylamine and thereafter 19 g anhydrous morpholine are added in small portions with ice-cooling. The solution is boiled for 2 hours under reflux. The precipitate is filtered off, and the solution is washed with dilute sulfuric acid, then with sodium hydrogen carbonate solution and finally with water, and then evaporated. The residual yellow oil soon crystallizes; the crystalline mass of the desired material is taken up with ether, filtered and then recrystallized from 90% ethanol, from which it separates in prisms. It is slightly soluble in water. Yield: 80%. melting point 120°C to 122°C.
Therapeutic Function
Sedative
Properties of trimetozine
Melting point: | 120-122° |
Boiling point: | 423.97°C (rough estimate) |
Density | 1.1755 (rough estimate) |
refractive index | 1.5230 (estimate) |
pka | -1.60±0.20(Predicted) |
form | Solid |
color | White to off-white |
Safety information for trimetozine
Computed Descriptors for trimetozine
New Products
2,2-diethoxyethanethioamide Tubulysin M (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin C (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 3-Aminocyclobutanone hydrochloride 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE 3-N-BOC-(S)-AMINO BUTYRONITRILE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 4-(Benzyloxy)-3-bromophenylacetic Acid Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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