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HomeProduct name listtrimetozine

trimetozine

  • CAS NO.:635-41-6
  • Empirical Formula: C14H19NO5
  • Molecular Weight: 281.3
  • MDL number: MFCD00023351
  • EINECS: 211-236-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
trimetozine Structural

What is trimetozine?

Originator

Opalene,Theraplix,France,1966

The Uses of trimetozine

A sedative with mild tranquilizing effects. Trimetozine has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine.

The Uses of trimetozine

antiurolithic, depigmentation, radiation protectant

The Uses of trimetozine

A sedative with mild tranquilizing effects. It has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine.

Definition

ChEBI: 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone is a member of morpholines.

Manufacturing Process

46 g 3,4,5-trimethoxybenzoyl chloride are dissolved in 300 ml anhydrous benzene and 25 g triethylamine and thereafter 19 g anhydrous morpholine are added in small portions with ice-cooling. The solution is boiled for 2 hours under reflux. The precipitate is filtered off, and the solution is washed with dilute sulfuric acid, then with sodium hydrogen carbonate solution and finally with water, and then evaporated. The residual yellow oil soon crystallizes; the crystalline mass of the desired material is taken up with ether, filtered and then recrystallized from 90% ethanol, from which it separates in prisms. It is slightly soluble in water. Yield: 80%. melting point 120°C to 122°C.

Therapeutic Function

Sedative

Properties of trimetozine

Melting point: 120-122°
Boiling point: 423.97°C (rough estimate)
Density  1.1755 (rough estimate)
refractive index  1.5230 (estimate)
pka -1.60±0.20(Predicted)
form  Solid
color  White to off-white

Safety information for trimetozine

Computed Descriptors for trimetozine

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