TRIMETHYLTIN CHLORIDE

Chemical properties

WHITE CRYSTALS

The Uses of TRIMETHYLTIN CHLORIDE

Trimethyltin chloride is an organotin reagent widely used in transferring trimethylstannyl groups onto the substrates to synthesize various organostannanes. Trimethylstannyl compounds derived from this reagent, are extensively used in the palladium-catalyzed Stille coupling reactions.

What are the applications of Application

Trimethyltin chloride is an organometallic compound for proteomics research

General Description

Solid.

Reactivity Profile

TRIMETHYLTIN CHLORIDE is in the family of tin compounds widely used as stabilizers for plastics, additives to paint(as antifouling agents). Some have catalytic properties. Examples include butyl tin, dibutyl tin oxide. Their main hazard is associated with their high toxicity, in skin adsorption or inhalation.

Hazard

A deadly poison. A reproductive hazard.

Health Hazard

(Non-Specific -- Tin Compounds, Organic) The material is an irritant to the skin and gastrointestinal tract. Contact may specifically damage the following target organs: central nervous system, eyes, liver, urinary tract, and skin.

Health Hazard

Trimethyltin chloride and other organotin compounds are highly toxic by ingestion, inhalation, or skin contact. Trimethyltin chloride can cause irritation and burns of the skin and eyes. Organotin compounds can affect the central nervous system. The degree of toxicity is greatest for compounds with three or four alkyl groups attached to tin. Diand monoalkyltin compounds are moderately toxic. The toxicity diminishes as the size of the alkyl groups increases. Thus, the oral LD50s in rats are as follows: dimethyltin dichloride, 74 to 237 mg/kg; tributyltin chloride, 122 to 349 mg/kg; dibutyltin oxide, 487 to 520 mg/kg; trioctyltin chloride, >4000 mg/kg.
Organotin compounds have been shown to cause reproductive effects in laboratory animals.

Fire Hazard

When heated to decomposition, TRIMETHYLTIN CHLORIDE emits toxic fumes of chlorides. Avoid decomposing heat.

Fire Hazard

Not a significant fire hazard. Emits toxic fumes in fire.

Flammability and Explosibility

Not a significant fire hazard. Emits toxic fumes in fire.

Safety Profile

A deadly poison by intravenous route. Experimental reproductive effects. See also TIN COMPOUNDS. When heated to decomposition it emits toxic fumes of Cl-.

Incompatibilities

Trimethyltin chloride and other organotin halides react with water to produce hydrogen halides. Organotin hydrides react with water to produce hydrogen gas, which is flammable and explosive.

Waste Disposal

Excess trimethyltin chloride or other organotin compound and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.