(TRIMETHYLSILYL)METHYLLITHIUM

CAS NO.：1822-00-0
Empirical Formula: C4H11LiSi
Molecular Weight: 94.16
MDL number: MFCD00010747
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is (TRIMETHYLSILYL)METHYLLITHIUM?

Chemical properties

Clear light yellow liquid

Physical properties

mp 112 °C.

The Uses of (TRIMETHYLSILYL)METHYLLITHIUM

Initiates polymerization and copolymerization of cyclosiloxanes.1 Alkylates metal complexes.2

The Uses of (TRIMETHYLSILYL)METHYLLITHIUM

Trimethylsilylmethyllithium is a reagent used in the methylenation of carbonyl compounds; reacts with carboxylic acid derivatives to provide α-silyl ketones; synthesis of allylsilanes. It participates in the reactions of Peterson Alkenation, Reaction with Carboxylic Acid Derivatives, Other Electrophiles, etc.

The Uses of (TRIMETHYLSILYL)METHYLLITHIUM

Initiates polymerization and copolymerization of cyclosiloxanes. Alkylates metal complexes.

Preparation

Trimethylsilylmethyllithium is obtained by reaction of (chloromethyl)- trimethylsilane with lithium metal in an inert solvent. It is also available by displacement of a heteroatom group based on sulfur, silicon, or tin.

Properties of (TRIMETHYLSILYL)METHYLLITHIUM

Melting point:	112-117 °C (decomp)
Boiling point:	35-36 °C
Density	0.65 g/mL at 25 °C
Flash point:	−57 °F
storage temp.	2-8°C
solubility	Sol ethereal solvents; reacts with protic solvents.
Specific Gravity	0.66
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
BRN	4123225

Safety information for (TRIMETHYLSILYL)METHYLLITHIUM

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H224:Flammable liquids H304:Aspiration hazard H314:Skin corrosion/irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.