TRIMETHYLCOLCHICINIC ACID
- CAS NO.：3482-37-9
- Empirical Formula: C19H21NO5
- Molecular Weight: 343.37
- MDL number: MFCD00082296
- EINECS: 222-464-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-10 15:15:42
What is TRIMETHYLCOLCHICINIC ACID?
Description
A minor alkaloid of the colchicine class, this base was first isolated from the seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta and subsequently by Russian workers from Merendera robusta Bge. Several specific rotations have been measured, e.g. [α]D - 184°, - 152° and - 180° (all in CHC13). The base is separated from the numerous accompanying alkaloids by chromatography and countercurrent distribution.
Chemical properties
Yellow-green Solid
The Uses of TRIMETHYLCOLCHICINIC ACID
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
References
Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972)
Properties of TRIMETHYLCOLCHICINIC ACID
| Melting point: | >230°C (dec.) |
| Boiling point: | 478.65°C (rough estimate) |
| Density | 1.2726 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | −20°C |
| solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol (Slightly), Methanol |
| form | Solid |
| color | Pale Green to Yellow |
Safety information for TRIMETHYLCOLCHICINIC ACID
Computed Descriptors for TRIMETHYLCOLCHICINIC ACID
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