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HomeProduct name listTRIMETHYLCOLCHICINIC ACID

TRIMETHYLCOLCHICINIC ACID

  • CAS NO.:3482-37-9
  • Empirical Formula: C19H21NO5
  • Molecular Weight: 343.37
  • MDL number: MFCD00082296
  • EINECS: 222-464-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-10 15:15:42
TRIMETHYLCOLCHICINIC ACID Structural

What is TRIMETHYLCOLCHICINIC ACID?

Description

A minor alkaloid of the colchicine class, this base was first isolated from the seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta and subsequently by Russian workers from Merendera robusta Bge. Several specific rotations have been measured, e.g. [α]D - 184°, - 152° and - 180° (all in CHC13). The base is separated from the numerous accompanying alkaloids by chromatography and countercurrent distribution.

Chemical properties

Yellow-green Solid

The Uses of TRIMETHYLCOLCHICINIC ACID

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

References

Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972)

Properties of TRIMETHYLCOLCHICINIC ACID

Melting point: >230°C (dec.)
Boiling point: 478.65°C (rough estimate)
Density  1.2726 (rough estimate)
refractive index  1.5000 (estimate)
storage temp.  −20°C
solubility  Chloroform (Slightly, Sonicated), DMSO (Slightly), Ethanol (Slightly), Methanol
form  Solid
color  Pale Green to Yellow

Safety information for TRIMETHYLCOLCHICINIC ACID

Computed Descriptors for TRIMETHYLCOLCHICINIC ACID

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