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HomeProduct name listtrimetaphan camsilate

trimetaphan camsilate

  • CAS NO.:68-91-7
  • Empirical Formula: C22H25N2OS.C10H16O4S
  • Molecular Weight: 597.817
  • EINECS: 200-696-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
trimetaphan camsilate Structural

What is trimetaphan camsilate?

Definition

ChEBI: The (S)-camphorsulfonate salt of trimethaphan.

General Description

Trimethaphan camsylate,(+)-1,3-dibenzyldecahydro2-oxoimidazo[4,5-c]thieno[1,2-α]-thiolium 2-oxo-10-bornanesulfonate (1:1)(Arfonad), consists of white crystals or a crystalline powderwith a bitter taste and a slight odor. It is soluble inwater and alcohol but only slightly soluble in acetone andether. The pH of a 1% aqueous solution is 5.0 to 6.0.

Clinical Use

This ganglionic blocking agent is short acting and isused for certain neurosurgical procedures in which excessivebleeding obscures the operative field. Certain craniotomiesare included among these operations. The actionof the drug is direct vasodilation, and because of its transientaction, it is subject to minute-by-minute control.This fleeting action, however, makes it useless for hypertensivecontrol. The drug is ineffective when given orally.The usual route of administration is intravenous.Trimethaphan camsylate is indicated in the treatment ofhypertensive emergencies to reduce blood pressure rapidly.These emergencies may include pulmonary hypertensionassociated with systemic hypertension and acutedissecting aneurysm.

Properties of trimetaphan camsilate

Melting point: 245 °C (decomp)
alpha  D20 +22.0° (c = 4 in water)

Safety information for trimetaphan camsilate

Computed Descriptors for trimetaphan camsilate

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