Trifluoroacetyl chloride

CAS NO.：354-32-5
Empirical Formula: C2ClF3O
Molecular Weight: 132.47
MDL number: MFCD00039307
EINECS: 206-556-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is Trifluoroacetyl chloride?

The Uses of Trifluoroacetyl chloride

Widely used in medicine, pesticides, organic intermediate and fine chemical.

Definition

ChEBI: Trifluoroacetyl chloride is an acyl chloride. It is functionally related to a trifluoroacetic acid.

General Description

A colorless gas. Shipped as a liquid under own vapor pressure. Contact with the unconfined liquid may frostbite unprotected skin. Very toxic by inhalation and may severely irritate skin, eyes, and mucous membranes. Under prolonged exposure to fire or heat the containers may rupture violently and rocket.

Air & Water Reactions

Reacts avidly with water and with moisture in the air to give fumes of hydrogen chloride, a water-soluble toxic gas.

Reactivity Profile

TRIFLUOROACETYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkalis. Reacts vigorously with amines and alkalis. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

Fire Hazard

Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Flammability and Explosibility

Not classified

Safety Profile

Corrosive to skin, eyes, and materials. When heated to decomposition it emits very toxic fumes of Fand Cl-. See also FLUORIDES and CHLORIDES.

Properties of Trifluoroacetyl chloride

Melting point:	−146 °C(lit.)
Boiling point:	−27 °C(lit.)
Density	1,335 g/cm³
vapor density	4.6 (vs air)
vapor pressure	546.6kPa at 25℃
Flash point:	-58.1±25.9℃
BRN	1098994
CAS DataBase Reference	354-32-5(CAS DataBase Reference)
EPA Substance Registry System	Trifluoroacetyl chloride (354-32-5)

Safety information for Trifluoroacetyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.