TRIETHYL 4-PHOSPHONOCROTONATE

Synonym(s):4-(Diethoxyphosphinyl)-2-butenoic acid ethyl ester;4-Phosphonocrotonic acid triethyl ester

CAS NO.：10236-14-3
Empirical Formula: C10H19O5P
Molecular Weight: 250.23
MDL number: MFCD00009192
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

TRIETHYL 4-PHOSPHONOCROTONATE Structural

What is TRIETHYL 4-PHOSPHONOCROTONATE?

Chemical properties

CLEAR LIGHT YELLOW LIQUID

The Uses of TRIETHYL 4-PHOSPHONOCROTONATE

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

The Uses of TRIETHYL 4-PHOSPHONOCROTONATE

Reactant for:

Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
Orally bioavailable GPR40 agonist synthesis
Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
Preaparation of mGlu4R agonists
Dearomatizing cyclization of nicotinyl-substituted esters and ketones

What are the applications of Application

Triethyl 4-phosphonocrotonate, mixture of isomers is used for mGlu4R agonist preparation

Properties of TRIETHYL 4-PHOSPHONOCROTONATE

Boiling point:	135 °C0.4 mm Hg(lit.)
Density	1.128 g/mL at 25 °C(lit.)
refractive index	n20/D 1.455(lit.)
Flash point:	>230 °F
form	Liquid
color	Clear light yellow
CAS DataBase Reference	10236-14-3(CAS DataBase Reference)

Safety information for TRIETHYL 4-PHOSPHONOCROTONATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.