Trichloroethanol

Synonym(s):ß,ß,ß-Trichloroethyl alcohol;2,2,2-Trichloroethanol;Trichloroethyl alcohol

CAS NO.：115-20-8
Empirical Formula: C2H3Cl3O
Molecular Weight: 149.4
MDL number: MFCD00004677
EINECS: 204-071-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-29 11:48:30

What is Trichloroethanol?

Chemical properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

The Uses of Trichloroethanol

2,2,2-Trichloroethanol (TCE) is an active metabolite of Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] (T774055), a sedative/hypnotic that increases cerebral blood flow (CBF).

The Uses of Trichloroethanol

Intermediate, anesthetic.

The Uses of Trichloroethanol

The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.
Some of its other application include:

Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.
Preparation of TCE ester of chlorosulfuric acid.
Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.

Definition

ChEBI: 2,2,2-trichloroethanol is a chloroethanol. It has a role as a mouse metabolite.

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andrectal routes. Human mutation data reported. Explosivereaction with concentrated sodium hydroxide solutions.When heated to decomposition it emits toxic fumes ofClí. Us

Properties of Trichloroethanol

Melting point:	17.8 °C (lit.)
Boiling point:	152-154 °C (lit.)
Density	1.56 g/mL at 20 °C (lit.)
vapor density	5.16 (vs air)
vapor pressure	1 mm Hg ( 20 °C)
refractive index	n20/D 1.49(lit.)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	83g/l
form	Liquid
pka	12.24(at 25℃)
Specific Gravity	1.560 (20/4℃)
color	Clear colorless to light yellow
Odor	ethereal odor
PH	5-6 (H2O, 20℃)(saturated solution)
Water Solubility	Slightly soluble in water.
Sensitive	Hygroscopic
Merck	14,9638
BRN	1697495
CAS DataBase Reference	115-20-8(CAS DataBase Reference)
NIST Chemistry Reference	Ethanol, 2,2,2-trichloro-(115-20-8)
EPA Substance Registry System	2,2,2-Trichloroethanol (115-20-8)

Safety information for Trichloroethanol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H318:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.