treosulfan

Synonym(s):(2S,3S)-Butanetetraol 1,4-dimesylate;(2S,3S)-Threitol 1,4-bismethanesulfonate;L-Threitol 1,4-bis(methanesulfonate);Threosulphan;Treosulphan

CAS NO.：299-75-2
Empirical Formula: C6H14O8S2
Molecular Weight: 278.3
MDL number: MFCD02258964
EINECS: 206-081-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is treosulfan?

The Uses of treosulfan

Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).

Background

Treosulfan is under investigation in Allogeneic Haematopoietic Stem Cell Transplantation. Treosulfan has been investigated for the treatment of Lymphoblastic Leukemia, Acute, Childhood.

Definition

ChEBI: Treosulfan is a methanesulfonate ester.

General Description

Odorless white crystalline powder.

Air & Water Reactions

Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .

Fire Hazard

Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Clinical Use

Alkylating agent for ovarian cancer

Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.

Metabolism

Not Available

Metabolism

Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.

Properties of treosulfan

Melting point:	76-78 °C
Boiling point:	359.3°C (rough estimate)
Density	1.305 (estimate)
refractive index	1.5630 (estimate)
storage temp.	Store at -20°C
solubility	Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka	12.36±0.20(Predicted)
form	Solid
color	Off-White to Pale Beige
CAS DataBase Reference	299-75-2
IARC	1 (Vol. 26, Sup 7, 100A) 2012
EPA Substance Registry System	Treosulfan (299-75-2)

Safety information for treosulfan

Signal word	Danger
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H340:Germ cell mutagenicity H350:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..…