Tos-PEG5 t-butyl ester
- CAS NO.：581065-94-3
- Empirical Formula: C22H36O9S
- Molecular Weight: 476.58
- MDL number: MFCD22574810
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-27 16:40:14
What is Tos-PEG5 t-butyl ester?
Description
Tos-PEG5-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
The Uses of Tos-PEG5 t-butyl ester
This compound is used in preparation of taxanes. Taxanes have improved its toxicity and solubility in aqueous solution compared to paciitaxel.
Properties of Tos-PEG5 t-butyl ester
| Boiling point: | 560.5±50.0 °C(Predicted) |
| Density | 1.151±0.06 g/cm3(Predicted) |
| refractive index | 1.49 |
| form | clear liquid |
| color | Colorless to Light yellow |
Safety information for Tos-PEG5 t-butyl ester
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Tos-PEG5 t-butyl ester
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