TOS-ARG-OME HCL

Synonym(s):Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem;TAME hydrochloride;TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I

CAS NO.：1784-03-8
Empirical Formula: C14H23ClN4O4S
Molecular Weight: 378.87
MDL number: MFCD00012578
EINECS: 217-235-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is TOS-ARG-OME HCL?

Description

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2

Chemical properties

white fine crystalline powder

The Uses of TOS-ARG-OME HCL

enzyme inhibitor

The Uses of TOS-ARG-OME HCL

Substrate for trypsin, thrombin, plasmin and other proteases.

The Uses of TOS-ARG-OME HCL

N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.

What are the applications of Application

N-4-Tosyl-L-arginine methyl ester hydrochloride is an Anaphase-Promoting Complex (APC) inhibitor

Biochem/physiol Actions

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

References

1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383

Properties of TOS-ARG-OME HCL

Melting point:	145-147(lit.)
alpha	-14 º (c=4, H2O)
refractive index	-14 ° (C=4, H2O)
storage temp.	-20°C
solubility	methanol: 50 mg/mL, clear, colorless
form	Fine Crystalline Powder
color	White
BRN	3922357
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference	1784-03-8(CAS DataBase Reference)

Safety information for TOS-ARG-OME HCL

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H224:Flammable liquids H304:Aspiration hazard H319:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H361:Reproductive toxicity H371:Specific target organ toxicity, single exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P331:Do NOT induce vomiting. P391:Collect spillage. Hazardous to the aquatic environment P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool.