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HomeProduct name listTOPOTECAN-D6

TOPOTECAN-D6

TOPOTECAN-D6 Structural

What is TOPOTECAN-D6?

Description

Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

Chemical properties

Light Yellow to Greenish Powder

The Uses of TOPOTECAN-D6

Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic

The Uses of TOPOTECAN-D6

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

What are the applications of Application

Topotecan-d6 is a labeled DNA Topo I (topoisomerase I) inhibitor

Properties of TOPOTECAN-D6

Melting point: 213-218°C (dec)
storage temp.  -20°C Freezer
solubility  aqueous acid: soluble; DMSO: slightly; Methanol: soluble
form  A solid
color  Light yellow to yellow
Stability: Hygroscopic
CAS DataBase Reference 1044904-10-0

Safety information for TOPOTECAN-D6

Computed Descriptors for TOPOTECAN-D6

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