Tolterodine
- CAS NO.:124937-51-5
- Empirical Formula: C22H31NO
- Molecular Weight: 325.49
- MDL number: MFCD00865264
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:11
What is Tolterodine?
The Uses of Tolterodine
A muscarinic receptor antagonist. Used in the treatment of urinary incontinence.
Background
Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Indications
For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Pharmacokinetics
Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.
Metabolism
Properties of Tolterodine
Boiling point: | 442.2±45.0 °C(Predicted) |
Density | 1.003±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMSO: ≥20mg/mL |
form | powder |
color | white to off-white |
Safety information for Tolterodine
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H361:Reproductive toxicity |
Precautionary Statement Codes |
P281:Use personal protective equipment as required. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Tolterodine
Abamectin manufacturer
ANWITA
KARPSCHEM LABORATORIES PVT. LTD.
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6 Di acetylpyridine 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 3-NITRO-5-ACETYL IMINODIBENZYL 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
124937-51-5 TOLTERODINE TARTRAT 2% SR PELLETS 98%View Details
124937-51-5 -
124937-51-5 96%View Details
124937-51-5 -
2,3 Dichloro-4-Hydroxy Aniline 39183-17-0 99%View Details
39183-17-0 -
17673-56-2 99%View Details
17673-56-2 -
13463-67-7 Titanium Dioxide 99%View Details
13463-67-7 -
143-07-7 99%View Details
143-07-7 -
20776-67-4 99%View Details
20776-67-4 -
acid blue 113, acid navy blue , wool navy blue 0View Details
3351-05-1