Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listtolciclate

tolciclate

  • CAS NO.:50838-36-3
  • Empirical Formula: C20H21NOS
  • Molecular Weight: 323.45
  • MDL number: MFCD01739034
  • EINECS: 256-792-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
tolciclate Structural

What is tolciclate?

Originator

Tolmicen,Carlo Erba,Italy,1979

Definition

ChEBI: Tolciclate is a monothiocarbamic ester. It has a role as an antifungal drug.

Indications

The indications for tolciclate are defined by its narrow spectrum and limited to the treatment of dermatophytoses. Because of inadequate penetration into the nail keratin, it is unlikely to be effective for the treatment of onychomycoses. On average, the efficacy of tolciclate in topical therapy of dermatomycoses is lower than that of most other antimycotics for topical treatment.

Manufacturing Process

Thiophosgene (1.15 g, 0.01 mol) in chloroform (40 ml) was slowly treated at room temperature with sodium 1,4-methano-1,2,3,4-tetrahydro-6- naphthoxide (1.82 g, 0.01 mol). After 30 minutes, N-methyl-m-toluidine (2.42 g, 0.02 mol) in chloroform (40 ml) was added dropwise to the solution so obtained at room temperature. The reaction mixture was stirred for 48 hours at room temperature and then refluxed for 2 hours. The solvent was evaporated, and the residue redissolved in water and extracted repeatedly with diethyl ether. The organic phase was dried (Na2SO4) and evaporated to dryness to give, after crystallization from isopropanol, O-(1,4-methano- 1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl)-thiocarbamate (1.3 g) melting point 92°C to 94°C.

Therapeutic Function

Topical antimycotic

Antimicrobial activity

In vitro, tolciclate has a narrow activity spectrum with good efficacy only towards dermatophytes. Isolates of susceptible species showing primary resistance or developing secondary resistance are rarely observed.

Properties of tolciclate

Melting point: 92-94°
Boiling point: 447.3±55.0 °C(Predicted)
Density  1.0965 (rough estimate)
refractive index  1.5800 (estimate)
pka -0.42±0.50(Predicted)

Safety information for tolciclate

Computed Descriptors for tolciclate

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.