Tizanidine hydrochloride
Synonym(s):5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
- CAS NO.:64461-82-1
- Empirical Formula: C9H9Cl2N5S
- Molecular Weight: 290.17
- MDL number: MFCD00798231
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Tizanidine hydrochloride?
Chemical properties
Off-White to pale Yellow Solid
Originator
Nimzox,Rapross Pharmaceuticals Pvt. Ltd.,India
The Uses of Tizanidine hydrochloride
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal).
The Uses of Tizanidine hydrochloride
Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,
The Uses of Tizanidine hydrochloride
Anticoagulant
What are the applications of Application
Tizanidine ? HCl is a centrally acting α2-adrenergic (α2-AR) agonist
Definition
ChEBI: Tizanidine hydrochloride is a benzothiadiazole.
Manufacturing Process
14 ml of benzoyl chloride are added to a solution of 11.5 g of ammonium thiocyanate in 150 ml of acetone in an ice bath and the mixture is then stirred for 10 min. This solution is heated to the boil at reflux together with 19 g of 4-amino-5-chloro-2,1,3-benzothiadiazole. The solution is cooled to room temperature and diluted with a 4-fold quantity of water. The precipitate is filtered off and rapidly brought to a boil together with 150 ml of a 2 N aqueous sodium hydroxide solution and kept at the boil for 5 min. The solution is cooled to room temperature, is acidified weakly with glacial acetic acid, the precipitate is filtered off, washed with ether and recrystallized from methanol. The N-(5-chloro-2,1,3-benzothiadiazol-4-yl)thiourea, obtained and this is boiled for 1 h together with 9 g of methyl iodide in 150 ml of methanol. After concentrating by evaporation, crude S-methyl-N-(5-chloro-2,1,3- benzothiadiazol-4-yl)isothiuronium iodide is obtained. 9.8 g of S-methyl-N-(5- chloro-2,1,3-benzothiadiazol-4-yl)isothiuronium iodide are heated to the boil at reflux for 1 h together with 50 ml of methanol and 1.8 ml of ethylene diamine. The solvent is then removed by evaporation and the moist residue is boiled at reflux for 1 h together with 20 ml of n-amyl alcohol. The mixture is subsequently shaken with 50 ml of chloroform and 150 ml of water until all the material is dissolved. 40 ml of a 2 N aqueous sodium hydroxide solution are added to the aqueous phase and extraction is effected with 200 ml of chloroform. The organic phase is dried and concentrated by evaporation. After recrystallizing the residue from methanol with the addition of some active charcoal, 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole, having a melting point of 221-223°C, is obtained. The 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole hydrochloride may be obtained by the teaction of 4-(2-imidazolin-2-yl-amino)-5-chloro- 2,1,3-benzothiadiazole with hydrochloric acid.
brand name
Tizanidine is INN and BAN.
Therapeutic Function
Muscle relaxant, Spasmolytic
Biological Activity
α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor.
storage
Desiccate at RT
Properties of Tizanidine hydrochloride
Melting point: | 280 °C |
Flash point: | 9℃ |
storage temp. | Inert atmosphere,Room Temperature |
solubility | H2O: ~29 mg/mL |
form | solid |
color | white |
Merck | 14,9485 |
CAS DataBase Reference | 64461-82-1(CAS DataBase Reference) |
Safety information for Tizanidine hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tizanidine hydrochloride
Abamectin manufacturer
Apotex Pharmachem India Pvt Ltd
Triveni Interchem Private Limited
Zydus Lifesciences Ltd.
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