Tioxolone
Synonym(s):Tioxolone
- CAS NO.:4991-65-5
- Empirical Formula: C7H4O3S
- Molecular Weight: 168.17
- MDL number: MFCD00005859
- EINECS: 225-653-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:04
What is Tioxolone?
Chemical properties
light yellow to beige powder
Originator
Acnosan,Unia
The Uses of Tioxolone
antiseborrhoic
The Uses of Tioxolone
6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.
Definition
ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.
Manufacturing Process
40 g potassium thiocyanate in 50 ml of water are added, while stirring at
room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized
copper sulfate in 250 ml of water. The black cupric thiocyanate formed
becomes colorless after a short time, which indicates that the introduction of
thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering
with suction and then washed with water; the filtrate is mixed with 50 ml of a
2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol
separates in the form of a colorless crystalline body. The yield amounts to 16
g. The new compound which melts at 149°C dissolves very easily in many
organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric
acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol-
2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of
fine crystals melting at 158°C.
Therapeutic Function
Antiseborreic, Antifungal, Keratolytic
General Description
Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.
Properties of Tioxolone
Melting point: | 158-160 °C(lit.) |
Boiling point: | 267.1°C (rough estimate) |
Density | 1.4844 (rough estimate) |
refractive index | 1.5151 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow |
pka | 8.14±0.20(Predicted) |
form | A solid |
color | Light yellow to yellow |
Merck | 9456 |
CAS DataBase Reference | 4991-65-5(CAS DataBase Reference) |
NIST Chemistry Reference | Tioxolone(4991-65-5) |
Safety information for Tioxolone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tioxolone
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