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HomeProduct name listTioxolone

Tioxolone

Synonym(s):Tioxolone

  • CAS NO.:4991-65-5
  • Empirical Formula: C7H4O3S
  • Molecular Weight: 168.17
  • MDL number: MFCD00005859
  • EINECS: 225-653-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-05 15:39:15
Tioxolone Structural

What is Tioxolone?

Chemical properties

light yellow to beige powder

Originator

Acnosan,Unia

The Uses of Tioxolone

antiseborrhoic

The Uses of Tioxolone

6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.

Definition

ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.

Manufacturing Process

40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.

Therapeutic Function

Antiseborreic, Antifungal, Keratolytic

General Description

Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.

Properties of Tioxolone

Melting point: 158-160 °C(lit.)
Boiling point: 267.1°C (rough estimate)
Density  1.4844 (rough estimate)
refractive index  1.5151 (estimate)
storage temp.  Inert atmosphere,Room Temperature
solubility  95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
pka 8.14±0.20(Predicted)
form  A solid
color  Light yellow to yellow
Merck  9456
CAS DataBase Reference 4991-65-5(CAS DataBase Reference)
NIST Chemistry Reference Tioxolone(4991-65-5)

Safety information for Tioxolone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Tioxolone

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