Timosaponin A-III
- CAS NO.：41059-79-4
- Empirical Formula: C39H64O13
- Molecular Weight: 740.92
- MDL number: MFCD01631164
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Timosaponin A-III?
The Uses of Timosaponin A-III
Timosaponin A3 suppresses certain human tumor processes and has the potential to be developed as an anticancer agent. Reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. Induction of mitochondrial-dependent apoptosis in HepG2 human hepatocellular carcinoma cells.Timosaponin A3 is a potent inhibitor of U46619, that induces rat platelet aggregation and exhibited superior selectivity for the TP receptor vs. other G protein-coupled receptors and a PKC activator.
What are the applications of Application
Timosaponin AIII is an inhibitor of mTORC1
Properties of Timosaponin A-III
| Melting point: | 317-322 °C |
| Boiling point: | 862.8±65.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml |
| form | White to off white solid. |
| pka | 12.85±0.70(Predicted) |
| color | White to off-white |
Safety information for Timosaponin A-III
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Timosaponin A-III
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