TIEMONIUM IODIDE

Originator

Visceralgine,Riom,France,1963

The Uses of TIEMONIUM IODIDE

Thiemonium Iodide is found in compositions containing bicifadine for the treatment of urinary incontinence.

Definition

ChEBI: Tiemonium iodide is an aralkylamine.

Manufacturing Process

(a) N-(3-hydroxy-3-phenyl-3-α-thienyl-propyl) morpholine was first prepared: The following quantities of reactants were mixed in a 2-liter balloon flask having 3 tubes fitted respectively with a mercury-sealed agitator, a reflux condenser having a calcium chloride seal, and a dropping funnel: Magnesium turnings 27 g (1.1 g at. wt) Bromobenzene 181 g (1.15 mol) Anhydrous ether 500 cc
(b) To the cold Grignard solution was added a solution containing: Thienyl-morpholinoethyl ketone 180 g (0.8 mol) Anhydrous ether 250 cc
The ketone, preferably prepared by a Grignard reaction, was added in such a way as to maintain the ether under constant reflux. When all of the solution had been added, the mixture was refluxed for a further hour. The mixture was then allowed to stand for 12 hours at ambient temperature, after which the reaction mass was extracted with ice and ammonium chloride in known manner.
(c) The ether solution was treated with 2 N hydrochloric acid solution and the amino-alcohol was obtained as the hydrochloride (yield approximately 60%); it was purified by recrystallization from methanol. The resulting product was dissolved in water, made alkaline with dilute NH4OHand was extracted with ether. After evaporation of the ether, the amino-alcohol was obtained as a base.
(d) To prepare the quaternary ammonium iodide, the amino-alcohol above was dissolved in a minimum amount of anhydrous ether and was treated with its own weight of methyl iodide. A well-crystallized product was obtained and was washed with anhydrous ether. (Melting point 189°C to 191°C).

Therapeutic Function

Spasmolytic, Anticholinergic