thonzylamine

CAS NO.：91-85-0
Empirical Formula: C16H22N4O
Molecular Weight: 286.37
MDL number: MFCD00865672
EINECS: 202-103-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is thonzylamine?

Toxicity

Doses of up to 300 mg/day for up to 4 days have produces no observable toxic effects in humans . In a chronic toxicity study, rats were given up to 200 mg/kg/day orally for 91 days with no observable toxic effects .

The Uses of thonzylamine

Thonzylamine is a selective H1-histamine receptor anatagonists. Tropine esterase inhibitor.

Background

Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.

Indications

Thozylamine is indicated for use in the symptomatic control of allergic rhinitis or other upper respiratory allergic symptoms . It is typically a part of combination over the counter products.

Definition

ChEBI: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-(2-pyrimidinyl)ethane-1,2-diamine is a member of methoxybenzenes.

General Description

An oily liquid. Used (in the form of the hydrochloride) as an antihistaminic.

Reactivity Profile

thonzylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products.

Pharmacokinetics

Thonzylamine is a first-generation antihistamine. It antagonizes the action of histamine to relief allergic symptoms like nasal congestion, runny nose, itchy eyes, itchy nose and throat, and sneezing

Synthesis

Thonzylamine is synthesized by treating the sodium salt of 2-(4-methoxybenzyl)aminopyrimidine with N,N-dimethyl-2-chloroethylamine .

Metabolism

Not Available

Properties of thonzylamine

Boiling point:	428.74°C (rough estimate)
Density	1.0426 (rough estimate)
refractive index	1.5850 (estimate)
storage temp.	Hygroscopic, Refrigerator, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
pka	pKa 2.17 (Uncertain);8.96 (Uncertain)
form	Oil
color	Light Brown to Brown
Water Solubility	5.441g/L(37.5 ºC)
Stability:	Hygroscopic
CAS DataBase Reference	91-85-0
EPA Substance Registry System	Thonzylamine (91-85-0)

Safety information for thonzylamine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P362:Take off contaminated clothing and wash before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…