Thiol-PEG6-t-butyl ester
- CAS NO.：1818294-40-4
- Empirical Formula: C19H38O8S
- Molecular Weight: 426.57
- MDL number: MFCD26127815
- Update Date: 2024-03-27 16:40:14
What is Thiol-PEG6-t-butyl ester?
Biological Activity
HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Thiol-PEG6-t-butyl ester
| Boiling point: | 488.8±45.0 °C(Predicted) |
| Density | 1.072±0.06 g/cm3(Predicted) |
| pka | 9?+-.0.10(Predicted) |
Safety information for Thiol-PEG6-t-butyl ester
Computed Descriptors for Thiol-PEG6-t-butyl ester
New Products
Tubulysin G Tubulysin C Tubulysin D Tubulysin E CYCLOBUTYLAMINE HYDROCHLORIDE 3-Aminocyclobutanone hydrochloride 4,4-DIFLUOROPIPERIDINE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropanol 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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