Thio-PEG2-t-butyl ester
- CAS NO.:1398044-50-2
- Empirical Formula: C11H22O4S
- Molecular Weight: 250.35
- MDL number: MFCD22574781
- Update Date: 2024-03-27 16:40:14
What is Thio-PEG2-t-butyl ester?
Biological Activity
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Thio-PEG2-t-butyl ester
Boiling point: | 330.6±27.0 °C(Predicted) |
Density | 1.041±0.06 g/cm3(Predicted) |
pka | 9?+-.0.10(Predicted) |
Safety information for Thio-PEG2-t-butyl ester
Computed Descriptors for Thio-PEG2-t-butyl ester
New Products
Tubulysin F Tubulysin G Tubulysin H 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE Cyclobutanamine, 3,3-difluoro- (9CI) 2,2-Difluoropropanol 3-FLUOROPYRROLIDINE HYDROCHLORIDE 3,6-Dihydro-2H-pyran-4-carbonitrile tert-Butyl (azetidin-3-yl)carbamate hydrochloride 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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