Thio-PEG2-t-butyl ester
- CAS NO.：1398044-50-2
- Empirical Formula: C11H22O4S
- Molecular Weight: 250.35
- MDL number: MFCD22574781
- Update Date: 2024-03-27 16:40:14
What is Thio-PEG2-t-butyl ester?
Biological Activity
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Thio-PEG2-t-butyl ester
| Boiling point: | 330.6±27.0 °C(Predicted) |
| Density | 1.041±0.06 g/cm3(Predicted) |
| pka | 9?+-.0.10(Predicted) |
Safety information for Thio-PEG2-t-butyl ester
Computed Descriptors for Thio-PEG2-t-butyl ester
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