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HomeProduct name listTHIOFLAVINE S

THIOFLAVINE S

Synonym(s):Direct Yellow 7

  • CAS NO.:1326-12-1
  • Empirical Formula: NULL
  • Molecular Weight: 0
  • MDL number: MFCD00071453
  • EINECS: 215-418-0
  • Update Date: 2024-11-19 23:02:33

What is THIOFLAVINE S?

The Uses of THIOFLAVINE S

Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain. Dyes and metabolites.

What are the applications of Application

Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain

Preparation

(a) primrose spirit alkali (C.I.Direct Yellow 59, C.I. 49000) methylation, then will be preparing sulphonated product (GP 1251738); (b) primrose spirit alkali stlfonation, then will product methylation (GP 53333).

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Properties and Applications

green light yellow. For golden is soluble in water, but soluble in ethanol as a green fluorescent yellow. The strong sulfuric acid in nearly colorless, with blue fluorescence, after diluted orange yellow precipitation. Used for cellulose fiber, wool, silk dyeing, silk printing, also can be used for leather color. Exhaust dyeing, good levelness.

Standard Acid Resistance Alkali Resistance Light Fastness Soaping Water
Fading Stain Fading Stain
ISO 2-3 4 1 1-2 2
AATCC 3 2 1 2 2

Properties of THIOFLAVINE S

storage temp.  Amber Vial, -20°C Freezer, Under inert atmosphere
solubility  ethanol: water (1:1): soluble1mg/mL
form  powder
Colour Index  49010
color  Dark Red to Very Dark Brown
Stability: Light Sensitive
EPA Substance Registry System C.I. Direct Yellow 7 (1326-12-1)

Safety information for THIOFLAVINE S

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for THIOFLAVINE S

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