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HomeProduct name listthielavin A

thielavin A

thielavin A Structural

What is thielavin A?

Description

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).

The Uses of thielavin A

The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.

The Uses of thielavin A

Thielavin A acts as an inhibitor of prostagladins biosynthesis.

What are the applications of Application

Thielavin A is apotent prostaglandin synthetase inhibitor

Properties of thielavin A

Melting point: 235-236 °C
Boiling point: 850.0±65.0 °C(Predicted)
Density  1.371±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: souble; DMSO: souble; Ethanol: soluble
form  White to off-white powder.
pka 2.82±0.28(Predicted)

Safety information for thielavin A

Computed Descriptors for thielavin A

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