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tetrahydroharmine

tetrahydroharmine Structural

What is tetrahydroharmine?

Description

This carboline alkaloid is present in Banisteria caapi, a plant indigenous toSouth America. It is dextrorotatory with [o:]l>s + 32° (c 1.0, CHCI3). One methoxyl group, a methyl group and two imino groups are present in the molecule.

The Uses of tetrahydroharmine

Tetrahydroharmine is a β-Carboline derivative. β-Carboline alkaloids are inhibitors of human monoamine oxidase enzymes. β-carboline derivatives were also reported to have antiviral and fungicidal activity. Tetrahydroharmine is related to 3,4-Dihydroharmine (D449718).

References

Hochstein, Paradies., J. Arner. Chern. Soc., 79, 5735 (1957)
Bernauer., Helv. Chirn. Acta, 47, 1075 (1960)
Koblicova, Trojanek., Chern. Ind., 1342 (1966)

Properties of tetrahydroharmine

Melting point: 199 °C
Boiling point: 399.2±37.0 °C(Predicted)
Density  1.145±0.06 g/cm3(Predicted)
storage temp.  Amber Vial, -20°C Freezer, Under inert atmosphere
solubility  Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 18.03±0.40(Predicted)
color  White to Off-White
Stability: Light Sensitive

Safety information for tetrahydroharmine

Computed Descriptors for tetrahydroharmine

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