Tetrachlorophthalic anhydride

Synonym(s):Tetrachlorophthalic anhydride;4,5,6,7-Tetrachloroisobenzofuran-1,3-dione;3,4,5,6-Tetrachlorophthalic anhydride;4,5,6,7-Tetrachloro-1,3-isobenzofurandione;Niagathal

CAS NO.：117-08-8
Empirical Formula: C8Cl4O3
Molecular Weight: 285.9
MDL number: MFCD00005920
EINECS: 204-171-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-11-23 20:02:38

Tetrachlorophthalic anhydride Structural

What is Tetrachlorophthalic anhydride?

Chemical properties

white needle-like crystals or powder

The Uses of Tetrachlorophthalic anhydride

Tetrachlorophthalic Anhydride is used in the synthesis of nucleoside analogues with a specific structure as apoptosis inducing active compounds. Also used in the synthesis of carbonic anhydrase inhbitors. Chlorinated Reactive Flame Retardant Intermediate

The Uses of Tetrachlorophthalic anhydride

Intermediate in dyes, pharmaceuticals, plasticizers, and other organic materials; flame-retardant in epoxy resins.

Definition

ChEBI: A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions.

General Description

Odorless needle-like crystals or white powder.

Air & Water Reactions

Sensitive to air and moisture.

Reactivity Profile

4,5,6,7-Tetrachloro-1,3-isobenzofurandione reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Fire Hazard

Flash point data for 4,5,6,7-Tetrachloro-1,3-isobenzofurandione are not available. 4,5,6,7-Tetrachloro-1,3-isobenzofurandione is probably combustible.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the anhydride from chloroform or *benzene, then sublime it in a vacuum. [Beilstein 17/11 V 260.]

Properties of Tetrachlorophthalic anhydride

Melting point:	253-257 °C(lit.)
Boiling point:	371 °C(lit.)
Density	1.49
vapor pressure	0.16 mm Hg ( 145 °C)
Flash point:	362°C
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly, Heated), DMSO (Heated), Methanol (Slightly, Heated)
form	Flakes
pka	3.01[at 20 ℃]
color	White to off-white
Water Solubility	0.8 mg/L (21 ºC)
Sensitive	Moisture Sensitive
BRN	211560
Exposure limits	ACGIH: TWA 0.002 mg/m3 (Skin)
Stability:	Stable. Reacts with water. Combustible. Incompatible with strong oxidizing agents. Air and moisture sensitive.
CAS DataBase Reference	117-08-8(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-(117-08-8)
EPA Substance Registry System	Tetrachlorophthalic anhydride (117-08-8)

Safety information for Tetrachlorophthalic anhydride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory H350:Carcinogenicity H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.