Tetrachlorophthalic anhydride
Synonym(s):Tetrachlorophthalic anhydride;4,5,6,7-Tetrachloroisobenzofuran-1,3-dione;3,4,5,6-Tetrachlorophthalic anhydride;4,5,6,7-Tetrachloro-1,3-isobenzofurandione;Niagathal
- CAS NO.:117-08-8
- Empirical Formula: C8Cl4O3
- Molecular Weight: 285.9
- MDL number: MFCD00005920
- EINECS: 204-171-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is Tetrachlorophthalic anhydride?
Chemical properties
white needle-like crystals or powder
The Uses of Tetrachlorophthalic anhydride
Tetrachlorophthalic Anhydride is used in the synthesis of nucleoside analogues with a specific structure as apoptosis inducing active compounds. Also used in the synthesis of carbonic anhydrase inhbitors. Chlorinated Reactive Flame Retardant Intermediate
The Uses of Tetrachlorophthalic anhydride
Intermediate in dyes, pharmaceuticals, plasticizers, and other organic materials; flame-retardant in epoxy resins.
Definition
ChEBI: A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions.
General Description
Odorless needle-like crystals or white powder.
Air & Water Reactions
Sensitive to air and moisture.
Reactivity Profile
4,5,6,7-Tetrachloro-1,3-isobenzofurandione reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
Fire Hazard
Flash point data for 4,5,6,7-Tetrachloro-1,3-isobenzofurandione are not available. 4,5,6,7-Tetrachloro-1,3-isobenzofurandione is probably combustible.
Flammability and Explosibility
Not classified
Purification Methods
Crystallise the anhydride from chloroform or *benzene, then sublime it in a vacuum. [Beilstein 17/11 V 260.]
Properties of Tetrachlorophthalic anhydride
Melting point: | 253-257 °C(lit.) |
Boiling point: | 371 °C(lit.) |
Density | 1.49 |
vapor pressure | 0.16 mm Hg ( 145 °C) |
Flash point: | 362°C |
storage temp. | Store below +30°C. |
solubility | Chloroform (Slightly, Heated), DMSO (Heated), Methanol (Slightly, Heated) |
form | Flakes |
pka | 3.01[at 20 ℃] |
color | White to off-white |
Water Solubility | 0.8 mg/L (21 ºC) |
Sensitive | Moisture Sensitive |
BRN | 211560 |
Exposure limits | ACGIH: TWA 0.002 mg/m3 (Skin) |
Stability: | Stable. Reacts with water. Combustible. Incompatible with strong oxidizing agents. Air and moisture sensitive. |
CAS DataBase Reference | 117-08-8(CAS DataBase Reference) |
NIST Chemistry Reference | 1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-(117-08-8) |
EPA Substance Registry System | Tetrachlorophthalic anhydride (117-08-8) |
Safety information for Tetrachlorophthalic anhydride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory H350:Carcinogenicity H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Tetrachlorophthalic anhydride
InChIKey | AUHHYELHRWCWEZ-UHFFFAOYSA-N |
Tetrachlorophthalic anhydride manufacturer
G C Int'L
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