(tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate
- CAS NO.:30392-41-7
- Empirical Formula: C45H64N2O5S
- Molecular Weight: 745.06506
- MDL number: MFCD01679558
- EINECS: 250-177-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate?
Description
Bitolterol is a prodrug that releases colterol on activation by esterases in the lung. Colterol is a direct-acting agonist, and the N-t-butyl group makes it β2-selective with a binding potency equivalent to that of isoetharine and terbutaline. The ester form is lipophilic, which helps to keep it local in the lung and resistant to COMT, which tends to increase its duration of action. Onset begins 2 to 4 minutes after administration, and the effect can last as long as 8 hours. It has a adverse effect profile similar to that of other β2-selective agonists, with less drowsiness and restlessness compared to other direct-acting agonists.
The Uses of (tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate
β2-adrenergic receptor agonist
Definition
ChEBI: The methanesulfonate salt of bitolterol. A beta2-adrenergic receptor agonist, it is used for relief of bronchospasm in conditions such as asthma, chronic bronchitis and emphysema.
brand name
Tornalate (Sanofi Aventis).
Properties of (tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate
Melting point: | 170-172° |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | Off-White to Light Beige |
Safety information for (tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate
Computed Descriptors for (tert-butyl)[beta-hydroxy-3,4-bis(p-toluoyloxy)phenethyl]ammonium methanesulphonate
New Products
Tubulysin A Tubulysin G Tubulysin D 2,2-Difluoropropylamine hydrochloride Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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