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HomeProduct name listtert-Butyl 3-(2-hydroxyethoxy)propanoate

tert-Butyl 3-(2-hydroxyethoxy)propanoate

tert-Butyl 3-(2-hydroxyethoxy)propanoate Structural

What is tert-Butyl 3-(2-hydroxyethoxy)propanoate?

Description

Hydroxy-PEG1-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

The Uses of tert-Butyl 3-(2-hydroxyethoxy)propanoate

tert-Butyl 3-(2-hydroxyethoxy)propanoate is a reactant in the synthesis of hydrophilic aminooxy linked and multivalent disaccharide cellobiose derivatives for chemoselective aldehyde/ketone conjugation

The Uses of tert-Butyl 3-(2-hydroxyethoxy)propanoate

tert-Butyl 3-(2-hydroxyethoxy)propanoate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis

Synthesis_671802-00-9
To a solution of anhydrous ethylene glycol (10 g, 161.1 mmol) in anhydrous THF (40 mL) was added sodium metal (62.0 mg, 2.70 mmol) and stirred at room temperature for 2 hours.Add tert-butyl acrylate (6.90, 53.7 mmol) and stir overnight.After quenching with water, the solvent was THF dried under reduced pressure, and extracted with ethyl acetate and water.The organic layer was separated, washed with brine, and dried over Na 2 SO 4.After filtration and evaporation, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 2:1) to obtain a colorless oil 44 (5.0 g, 26.3 mmol, 49% yield)

Properties of tert-Butyl 3-(2-hydroxyethoxy)propanoate

Boiling point: 274.0±15.0 °C(Predicted)
Density  1.031±0.06 g/cm3(Predicted)
storage temp.  2-8°C
pka 14.36±0.10(Predicted)
color  Yellowish
Water Solubility  Water: 100 mg/mL (525.65 mM)

Safety information for tert-Butyl 3-(2-hydroxyethoxy)propanoate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for tert-Butyl 3-(2-hydroxyethoxy)propanoate

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