Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listTAXIFOLIN 3-O-RHAMNOSIDE

TAXIFOLIN 3-O-RHAMNOSIDE

Synonym(s):Astilbin;Dihydroquercetin 3-rhamnoside;Taxifolin 3-rhamnoside

  • CAS NO.:29838-67-3
  • Empirical Formula: C21H22O11
  • Molecular Weight: 450.4
  • MDL number: MFCD20274680
  • EINECS: 694-695-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
TAXIFOLIN 3-O-RHAMNOSIDE Structural

What is TAXIFOLIN 3-O-RHAMNOSIDE?

Description

Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.

The Uses of TAXIFOLIN 3-O-RHAMNOSIDE

Astilbin displays anti-depressant activity involving monoaminergic neurotransmitters an the BDNF signal pathway. Anti-oxidant.

Definition

ChEBI: A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.

Properties of TAXIFOLIN 3-O-RHAMNOSIDE

Melting point: 180 °C (decomp)
Boiling point: 801.1±65.0 °C(Predicted)
Density  1.74
storage temp.  Sealed in dry,2-8°C
solubility  H2O: soluble1mg/mL, clear, colorless
pka 7.34±0.60(Predicted)
form  A crystalline solid
color  White to off-white

Safety information for TAXIFOLIN 3-O-RHAMNOSIDE

Signal word Warning
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for TAXIFOLIN 3-O-RHAMNOSIDE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.