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HomeProduct name listTAXIFOLIN 3-O-RHAMNOSIDE

TAXIFOLIN 3-O-RHAMNOSIDE

Synonym(s):Astilbin;Dihydroquercetin 3-rhamnoside;Taxifolin 3-rhamnoside

  • CAS NO.:29838-67-3
  • Empirical Formula: C21H22O11
  • Molecular Weight: 450.4
  • MDL number: MFCD20274680
  • EINECS: 694-695-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
TAXIFOLIN 3-O-RHAMNOSIDE Structural

What is TAXIFOLIN 3-O-RHAMNOSIDE?

Description

Astilbin is a flavonoid that has been found in S. glabra and has diverse biological activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive oxygen species (ROS) in HEK293 cells when used at a concentration of 200 μM. Astilbin (50 mg/kg) increases renal glutathione (GSH) levels and superoxide dismutase (SOD) and catalase activity and reduces serum creatinine and blood urea nitrogen (BUN) levels, renal IL-1β, IL-6, and TNF-α levels, apoptosis in kidney tissue, and kidney injury in a mouse model of cisplatin-induced nephrotoxicity. It reduces loss of dopaminergic neurons in the substantia nigra and increases striatal GSH levels and SOD activity in a mouse model of MPTP-induced Parkinson''s disease when administered at a dose of 50 mg/kg per day. Astilbin also reduces descent time in a pole test and increases traction test score in a mouse model of Parkinson''s disease, indicating reduced motor deficits. It reduces cell viability of MDA-MB-231 and MCF-7 cells (IC50s = 167.9 and 191.6 μM, respectively), as well as inhibits migration and increases apoptosis when used at concentrations of 50 and 200 μM. Astilbin (20 mg/kg every other day for 14 days) reduces tumor growth in an MCF-7 mouse xenograft model.

The Uses of TAXIFOLIN 3-O-RHAMNOSIDE

Astilbin displays anti-depressant activity involving monoaminergic neurotransmitters an the BDNF signal pathway. Anti-oxidant.

Definition

ChEBI: A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.

Properties of TAXIFOLIN 3-O-RHAMNOSIDE

Melting point: 180 °C (decomp)
Boiling point: 801.1±65.0 °C(Predicted)
Density  1.74
storage temp.  Sealed in dry,2-8°C
solubility  H2O: soluble1mg/mL, clear, colorless
pka 7.34±0.60(Predicted)
form  A crystalline solid
color  White to off-white

Safety information for TAXIFOLIN 3-O-RHAMNOSIDE

Signal word Warning
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for TAXIFOLIN 3-O-RHAMNOSIDE

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