Taurohyodeoxycholic acid sodium salt hydrate
- CAS NO.：38411-85-7
- Empirical Formula: C26H46NNaO6S
- Molecular Weight: 523.7
- MDL number: MFCD00271496
- Update Date: 2024-11-19 23:02:33
What is Taurohyodeoxycholic acid sodium salt hydrate?
Description
Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid . THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats. Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA; ) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats. THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.
The Uses of Taurohyodeoxycholic acid sodium salt hydrate
Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions.
General Description
Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent.
Properties of Taurohyodeoxycholic acid sodium salt hydrate
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
Safety information for Taurohyodeoxycholic acid sodium salt hydrate
Computed Descriptors for Taurohyodeoxycholic acid sodium salt hydrate
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