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HomeProduct name listTAMARIXETIN

TAMARIXETIN

Synonym(s):3,3′,5,7-Tetrahydroxy 4′-methoxyflavone;3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;4′-Methylquercetin;Quercetin 4′-methyl ether;Tamaraxetin

  • CAS NO.:603-61-2
  • Empirical Formula: C16H12O7
  • Molecular Weight: 316.26
  • MDL number: MFCD00017308
  • EINECS: 210-050-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
TAMARIXETIN Structural

What is TAMARIXETIN?

Description

4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).

The Uses of TAMARIXETIN

A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

What are the applications of Application

4′-O-Methyl Quercetin is A major metabolite of the flavanoid Quercetin with antioxidant properties.

Definition

ChEBI: A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Properties of TAMARIXETIN

Melting point: 265-268°C
Boiling point: 601.8±55.0 °C(Predicted)
Density  1.634±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO: Slightly Soluble; Methanol: Slightly Soluble
form  A solid
pka 6.31±0.40(Predicted)
color  Yellow to brown

Safety information for TAMARIXETIN

Computed Descriptors for TAMARIXETIN

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