t-Boc-N-amido-PEG1-acid
- CAS NO.：1260092-44-1
- Empirical Formula: C10H19NO5
- Molecular Weight: 233.26
- MDL number: MFCD22574796
- Update Date: 2024-10-23 13:36:13
What is t-Boc-N-amido-PEG1-acid?
Description
t-Boc-N-amido-PEG1-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Biological Activity
Boc-NH-PEG1-CH2CH2COOH is a cleavable ADC linker containing 1 unit PEG, and also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used for the synthesis of antibody-drug conjugates (ADC) and PROTACs .
Properties of t-Boc-N-amido-PEG1-acid
| Boiling point: | 385.0±27.0 °C(Predicted) |
| Density | 1.127±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 4.29±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for t-Boc-N-amido-PEG1-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for t-Boc-N-amido-PEG1-acid
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