Succinylsulfathiazole
- CAS NO.：116-43-8
- Empirical Formula: C13H13N3O5S2
- Molecular Weight: 355.39
- MDL number: MFCD00022437
- EINECS: 204-141-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-27 15:57:40
What is Succinylsulfathiazole?
Originator
Sulfasuxidine,MSD,US,1942
The Uses of Succinylsulfathiazole
Succinylsulfathiazole is antibacterial
The Uses of Succinylsulfathiazole
Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
What are the applications of Application
Succinylsulfathiazole is an inhibitor of DHFR
Definition
ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.
Manufacturing Process
3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2- sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for five minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water. The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole, melting at 184°C to 186°C.
Therapeutic Function
Antibacterial (intestinal)
Properties of Succinylsulfathiazole
| Melting point: | 193.5°C |
| Density | 1.4807 (rough estimate) |
| refractive index | 1.6390 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 1 M NaOH: soluble50mg/mL |
| form | powder |
| pka | pKa 4.5 (Uncertain) |
| color | white to off-white |
| Water Solubility | 0.49g/L(38 ºC) |
| λmax | 282nm(H2O (pH 3.3 - 5))(lit.) |
| Merck | 14,8877 |
| BRN | 349989 |
| CAS DataBase Reference | 116-43-8(CAS DataBase Reference) |
| EPA Substance Registry System | Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]- (116-43-8) |
Safety information for Succinylsulfathiazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Succinylsulfathiazole
New Products
Tubulysin C Tubulysin M (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin H Potassium HMDS (1.0 M in THF) CYCLOBUTYLAMINE HYDROCHLORIDE tetrahydro-4-methyl-2H-pyran 4,4-DIFLUOROPIPERIDINE 3-N-BOC-(S)-AMINO BUTYRONITRILE 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROCYCLOHEXANAMINE (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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