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HomeProduct name listSuccinylsulfathiazole

Succinylsulfathiazole

  • CAS NO.:116-43-8
  • Empirical Formula: C13H13N3O5S2
  • Molecular Weight: 355.39
  • MDL number: MFCD00022437
  • EINECS: 204-141-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Succinylsulfathiazole Structural

What is Succinylsulfathiazole?

Originator

Sulfasuxidine,MSD,US,1942

The Uses of Succinylsulfathiazole

Succinylsulfathiazole is antibacterial

The Uses of Succinylsulfathiazole

Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.

Definition

ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.

What are the applications of Application

Succinylsulfathiazole is an inhibitor of DHFR

Manufacturing Process

3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2- sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for five minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water. The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole, melting at 184°C to 186°C.

Therapeutic Function

Antibacterial (intestinal)

Properties of Succinylsulfathiazole

Melting point: 193.5°C
Density  1.4807 (rough estimate)
refractive index  1.6390 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  1 M NaOH: soluble50mg/mL
form  powder
pka pKa 4.5 (Uncertain)
color  white to off-white
Water Solubility  0.49g/L(38 ºC)
λmax 282nm(H2O (pH 3.3 - 5))(lit.)
Merck  14,8877
BRN  349989
CAS DataBase Reference 116-43-8(CAS DataBase Reference)
EPA Substance Registry System Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]- (116-43-8)

Safety information for Succinylsulfathiazole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Succinylsulfathiazole

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