Succinylsulfathiazole
- CAS NO.：116-43-8
- Empirical Formula: C13H13N3O5S2
- Molecular Weight: 355.39
- MDL number: MFCD00022437
- EINECS: 204-141-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is Succinylsulfathiazole?
Originator
Sulfasuxidine,MSD,US,1942
The Uses of Succinylsulfathiazole
Succinylsulfathiazole is antibacterial
The Uses of Succinylsulfathiazole
Succinylsulfathiazole is a sulfonamide antibiotic that was shown to inhibit bacteria that are responsible for folate production. Succinylsulfathiazole was used in various folate deficiency studies to block the synthesis of folic acid.
Definition
ChEBI: N-succinylsulfathiazole is a member of 1,3-thiazoles. It is functionally related to a sulfathiazole.
What are the applications of Application
Succinylsulfathiazole is an inhibitor of DHFR
Manufacturing Process
3.92 g of succinic anhydride was added to a boiling suspension of 10 g of 2- sulfanilamidothiazole in 100 cc of alcohol. The mixture was then refluxed for five minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water. The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-succinylsulfanilamidothiazole, melting at 184°C to 186°C.
Therapeutic Function
Antibacterial (intestinal)
Properties of Succinylsulfathiazole
| Melting point: | 193.5°C |
| Density | 1.4807 (rough estimate) |
| refractive index | 1.6390 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 1 M NaOH: soluble50mg/mL |
| form | powder |
| pka | pKa 4.5 (Uncertain) |
| color | white to off-white |
| Water Solubility | 0.49g/L(38 ºC) |
| λmax | 282nm(H2O (pH 3.3 - 5))(lit.) |
| Merck | 14,8877 |
| BRN | 349989 |
| CAS DataBase Reference | 116-43-8(CAS DataBase Reference) |
| EPA Substance Registry System | Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]- (116-43-8) |
Safety information for Succinylsulfathiazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Succinylsulfathiazole
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