SUBSTANCE P
- CAS NO.:12769-48-1
- Empirical Formula: C63H98N18O13S
- Molecular Weight: 1347.63
- MDL number: MFCD00076780
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:32
What is SUBSTANCE P?
The Uses of SUBSTANCE P
Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.
What are the applications of Application
Substance P is a synthetic ligand for NK-1R
Definition
ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).
Mechanism of action
Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.
Clinical Use
The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.
Properties of SUBSTANCE P
storage temp. | -20°C |
Safety information for SUBSTANCE P
Computed Descriptors for SUBSTANCE P
New Products
Tubulysin M Tubulysin F Tubulysin H (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 3-N-BOC-(S)-AMINO BUTYRONITRILE 4-(Benzyloxy)-3-bromophenylacetic Acid 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 1-(1,1-Difluoroethyl)-2-fluorobenzene 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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