STRYCHNINE HYDROCHLORIDE

CAS NO.：1421-86-9
Empirical Formula: C21H23ClN2O2
Molecular Weight: 370.87
MDL number: MFCD00058174
EINECS: 215-826-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:55

What is STRYCHNINE HYDROCHLORIDE?

The Uses of STRYCHNINE HYDROCHLORIDE

Strychnine Hydrochloride acts as an antagonist for cholinesterases and beta amyloid aggregation.

The Uses of STRYCHNINE HYDROCHLORIDE

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Definition

ChEBI: A hydrochloride obtained by combining strychnine with one molar equivalent of hydrogen chloride.

Biological Activity

Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α 7 receptors and non-competitive antagonism at α 4 β 2 receptors.

Biochem/physiol Actions

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

Properties of STRYCHNINE HYDROCHLORIDE

Melting point:	295 °C
storage temp.	Store at RT
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly, Slightly)
form	Solid
color	White to Light Beige
Merck	14,8855
Stability:	Hygroscopic
CAS DataBase Reference	1421-86-9(CAS DataBase Reference)
EPA Substance Registry System	Strychnine hydrochloride (1421-86-9)

Safety information for STRYCHNINE HYDROCHLORIDE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment.