SR-95531
Synonym(s):2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide;GABA A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531;GABAA Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531;Gabazine;SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem
- CAS NO.：104104-50-9
- Empirical Formula: C15H18BrN3O3
- Molecular Weight: 368.23
- MDL number: MFCD09055424
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is SR-95531?
Description
SR 95531 is a derivative of γ-
The Uses of SR-95531
Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.
What are the applications of Application
SR 95531 Hydrobromide is a selective GABAA receptor antagonist
Biological Activity
Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.
Biochem/physiol Actions
SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.
storage
Room temperature
Properties of SR-95531
| Melting point: | 200 °C(Solv: ethanol (64-17-5)) |
| storage temp. | Store at RT |
| solubility | DMSO: 30 mg/mL |
| form | solid |
| color | white |
Safety information for SR-95531
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SR-95531
New Products
4-Fluorophenylacetic acid (S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate 4-AMINO-2-CHLOROPYRIDINE Benzyl {1-[4-(4- Fluorobenzylcarbamoyl)-5-hydroxy-1- methyl-6-oxo-1,6-dihydropyrimidin-2- yl]-1-methylethyl}-carbamate R,R-Chiraphite 4-BROMO-2-METHYLBENZOIC ACID N-Boc-1,4-butanediamine 2-AMINO-6-METHOXYBENZOTHIAZOLE Cyaclopentane carboxylic acid 3-Nitropyrazole 4-Pyrazolecarboxylic acid 1-Nitropyrazole 2H-Cyclopenta[b]furan-2,5-diol, hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1- buten-1-yl]-, (3aR,4R,5R,6aS)- 2,5-Dibromopyridine 2-Bromo-6-methyl-4-nitrobenzenamine 2-Chloro-5-fluoro-3-methylphenol (R)-3-Amino-4-(2,4-difluorophenyl)butanoic acid hydrochlorideRelated products of tetrahydrofuran
![SR95531, [BUTYRYL-2,3-3H]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB9684539.gif)
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