SPERMINE TETRAHYDROCHLORIDE
Synonym(s):N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride;Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem
- CAS NO.:306-67-2
- Empirical Formula: C10H30Cl4N4
- Molecular Weight: 348.18
- MDL number: MFCD00012914
- EINECS: 206-189-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is SPERMINE TETRAHYDROCHLORIDE?
Chemical properties
White to off-white powder
The Uses of SPERMINE TETRAHYDROCHLORIDE
Spermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-?enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes.
The Uses of SPERMINE TETRAHYDROCHLORIDE
Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.
The Uses of SPERMINE TETRAHYDROCHLORIDE
Used to precipitate DNA from low salt aqueous buffers.
What are the applications of Application
Spermine, Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα
Biological Activity
Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
storage
Desiccate at +4°C
Purification Methods
Its pK values are similar to those of spermidine above. Purify it as for spermidine trihydrochloride above. [Beilstein 4 IV 1301.]
Properties of SPERMINE TETRAHYDROCHLORIDE
Melting point: | 310-311 °C (dec.)(lit.) |
Density | 1.01 g/mL at 20 °C |
storage temp. | room temp |
solubility | H2O: 1 M at 20 °C, clear, colorless |
form | powder |
color | White to Almost white |
PH | 4.5-7.0 (25℃, 1M in H2O) |
Water Solubility | Soluble in water (348.2 g/L at 20°C). |
λmax | λ: 260 nm Amax: 0.2 λ: 280 nm Amax: 0.15 |
BRN | 3911771 |
InChI | InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H |
CAS DataBase Reference | 306-67-2(CAS DataBase Reference) |
EPA Substance Registry System | Spermine tetrahydrochloride (306-67-2) |
Safety information for SPERMINE TETRAHYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for SPERMINE TETRAHYDROCHLORIDE
InChIKey | XLDKUDAXZWHPFH-UHFFFAOYSA-N |
SMILES | C(CNCCCN)CCNCCCN.Cl.Cl.Cl.Cl |
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