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HomeProduct name listSPERMINE TETRAHYDROCHLORIDE

SPERMINE TETRAHYDROCHLORIDE

Synonym(s):N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride;Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem

  • CAS NO.:306-67-2
  • Empirical Formula: C10H30Cl4N4
  • Molecular Weight: 348.18
  • MDL number: MFCD00012914
  • EINECS: 206-189-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
SPERMINE TETRAHYDROCHLORIDE Structural

What is SPERMINE TETRAHYDROCHLORIDE?

Chemical properties

White to off-white powder

The Uses of SPERMINE TETRAHYDROCHLORIDE

Spermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-?enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes.

The Uses of SPERMINE TETRAHYDROCHLORIDE

Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.

The Uses of SPERMINE TETRAHYDROCHLORIDE

Used to precipitate DNA from low salt aqueous buffers.

What are the applications of Application

Spermine, Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα

Biological Activity

Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

storage

Desiccate at +4°C

Purification Methods

Its pK values are similar to those of spermidine above. Purify it as for spermidine trihydrochloride above. [Beilstein 4 IV 1301.]

Properties of SPERMINE TETRAHYDROCHLORIDE

Melting point: 310-311 °C (dec.)(lit.)
Density  1.01 g/mL at 20 °C
storage temp.  room temp
solubility  H2O: 1 M at 20 °C, clear, colorless
form  powder
color  White to Almost white
PH 4.5-7.0 (25℃, 1M in H2O)
Water Solubility  Soluble in water (348.2 g/L at 20°C).
λmax λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.15
BRN  3911771
InChI InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
CAS DataBase Reference 306-67-2(CAS DataBase Reference)
EPA Substance Registry System Spermine tetrahydrochloride (306-67-2)

Safety information for SPERMINE TETRAHYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for SPERMINE TETRAHYDROCHLORIDE

InChIKey XLDKUDAXZWHPFH-UHFFFAOYSA-N
SMILES C(CNCCCN)CCNCCCN.Cl.Cl.Cl.Cl

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