SOYASAPONIN I
Synonym(s):SCM 3B;Soyasaponin Bb
- CAS NO.:51330-27-9
- Empirical Formula: C48H78O18
- Molecular Weight: 943.13
- MDL number: MFCD02752366
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is SOYASAPONIN I?
Description
Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities. It selectively inhibits human recombinant and porcine kidney renin (IC50s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 μg/ml. Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 μM. It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress. Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid .
The Uses of SOYASAPONIN I
Soyasaponin I has been used:
- to test its effect on migration and invasion of ovarian cancer cell lines
- as standard for the quantification of saponins from quinoa and fenugreek samples
- as L-15 medium supplement for Zebrafish liver cell lines
Definition
ChEBI: Soyasaponin I is a triterpenoid saponin that is composed of soyasapogenol B having an alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid moiety attached at the 3-position via a glycosidic linkage. It has a role as a sialyltransferase inhibitor. It is a pentacyclic triterpenoid, a triterpenoid saponin, a trisaccharide derivative and a carbohydrate acid derivative. It is functionally related to a soyasapogenol B. It is a conjugate acid of a soyasaponin I(1-).
General Description
Soyasaponin I is an oleanene-type triterpenoid aglycone and is a group B soyasaponin. It is an amphiphilic molecule and is metabolized by intestinal bacteria into sugars and aglycones.
Biochem/physiol Actions
Antioxidant and anti-inflammatory saponin found in soybean. Attenuates TNBS-induced colitis in mice. The structure consists of a glycoside moiety and triterpene derivative. Sialytransferase inhibitor and renin inhibitor.
Properties of SOYASAPONIN I
Melting point: | 220-222 °C(Solv: methanol (67-56-1)) |
Boiling point: | 1024.2±65.0 °C(Predicted) |
Density | 1.41 |
storage temp. | 2-8°C |
solubility | ethanol: soluble1mg/mL, clear, colorless |
form | powder |
pka | 2.76±0.70(Predicted) |
color | White |
Stability: | Hygroscopic |
Safety information for SOYASAPONIN I
Computed Descriptors for SOYASAPONIN I
InChIKey | PTDAHAWQAGSZDD-IOVCITQVSA-N |
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