Sorbinil
- CAS NO.:68367-52-2
- Empirical Formula: C11H9FN2O3
- Molecular Weight: 236.2
- MDL number: MFCD00867380
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Sorbinil?
The Uses of Sorbinil
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
The Uses of Sorbinil
Enzyme inhibitor (aldose reductase).
Definition
ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Properties of Sorbinil
Melting point: | 241-243° |
alpha | D25 +54.0° (c = 1 in methanol) |
Density | 1.52 |
storage temp. | 2-8°C |
solubility | DMSO: ≥20mg/mL |
form | powder |
pka | 8.91±0.20(Predicted) |
color | white to off-white |
optical activity | [α]/D +50 to +60°, c = 1 in methanol |
Safety information for Sorbinil
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Sorbinil
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
(S)-(+)-NIRVANOL
FIDARESTAT
Sorbinil
1-(3-FLUOROPHENYL)PROPYLAMINE
6-FLUORO-4-CHROMANONE HYDANTOIN
2-ETHOXYPHENETHYLAMINE
N-(2-METHOXYPHENETHYL)UREA
H-PHG-NH2 HCL
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