Sorbinil
- CAS NO.:68367-52-2
- Empirical Formula: C11H9FN2O3
- Molecular Weight: 236.2
- MDL number: MFCD00867380
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is Sorbinil?
The Uses of Sorbinil
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
The Uses of Sorbinil
Enzyme inhibitor (aldose reductase).
Definition
ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Properties of Sorbinil
Melting point: | 241-243° |
alpha | D25 +54.0° (c = 1 in methanol) |
Density | 1.52 |
storage temp. | 2-8°C |
solubility | DMSO: ≥20mg/mL |
form | powder |
pka | 8.91±0.20(Predicted) |
color | white to off-white |
optical activity | [α]/D +50 to +60°, c = 1 in methanol |
Safety information for Sorbinil
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Sorbinil
New Products
Tubulysin B Tubulysin A Tubulysin E Tubulysin C Potassium HMDS (1.0 M in THF) 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-(1,1-Difluoroethyl)-2-fluorobenzene Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
(S)-(+)-NIRVANOL
FIDARESTAT
Sorbinil
1-(3-FLUOROPHENYL)PROPYLAMINE
6-FLUORO-4-CHROMANONE HYDANTOIN
2-ETHOXYPHENETHYLAMINE
N-(2-METHOXYPHENETHYL)UREA
H-PHG-NH2 HCL
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