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HomeProduct name listSorbinil

Sorbinil

Sorbinil Structural

What is Sorbinil?

The Uses of Sorbinil

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.

The Uses of Sorbinil

Enzyme inhibitor (aldose reductase).

Definition

ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.

Biochem/physiol Actions

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.

Properties of Sorbinil

Melting point: 241-243°
alpha  D25 +54.0° (c = 1 in methanol)
Density  1.52
storage temp.  2-8°C
solubility  DMSO: ≥20mg/mL
form  powder
pka 8.91±0.20(Predicted)
color  white to off-white
optical activity [α]/D +50 to +60°, c = 1 in methanol

Safety information for Sorbinil

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for Sorbinil

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