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HomeProduct name listSodium Palmitate

Sodium Palmitate

Synonym(s):Hexadecanoic acid sodium salt;Palmitic acid sodium salt

  • CAS NO.:408-35-5
  • Empirical Formula: C16H31NaO2
  • Molecular Weight: 278.41
  • MDL number: MFCD00002749
  • EINECS: 206-988-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Sodium Palmitate Structural

What is Sodium Palmitate?

Chemical properties

white powder

Chemical properties

Sodium palmitate, white solid, soluble, froth or foam upon shaking the H2O solution (soap), formed by reaction of NaOH and palmitic acid (in alcoholic solution) and evaporating. Used as a source of palmitate.

The Uses of Sodium Palmitate

Sodium Palmitate is the sodium salt of palmitic acid. It functions as a binder, emulsifier, and anticaking agent.

The Uses of Sodium Palmitate

Polymerization catalyst for synthetic rubbers, laundry and toilet soaps, detergents, cosmetics, pharmaceuticals, printing inks, and as an emulsi- fier.

The Uses of Sodium Palmitate

Sodium palmitate (PA) has been used:

  • to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
  • to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
  • as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

What are the applications of Application

Sodium palmitate is a common saturated fatty acid

Hazard

A poison. Combustible.

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Safety Profile

A poison by intravenous route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

It crystallises from EtOH and is dried in an oven. [Beilstein 2 IV 1157.]

Properties of Sodium Palmitate

Melting point: 283-290 °C (lit.)
storage temp.  2-8°C
solubility  very faint turbidity in hot EtOH50vol%
form  Powder
color  White
BRN  3575882
CAS DataBase Reference 408-35-5(CAS DataBase Reference)
EPA Substance Registry System Hexadecanoic acid, sodium salt (408-35-5)

Safety information for Sodium Palmitate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Sodium Palmitate

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