Sodium levothyroxine pentahydrate
Synonym(s):3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L -alanine sodium salt;Sodium levothyroxine;T4
- CAS NO.：6106-07-6
- Empirical Formula: C15H20I4NNaO9
- Molecular Weight: 888.93
- MDL number: MFCD00149110
- EINECS: 682-494-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-10 19:09:04
What is Sodium levothyroxine pentahydrate?
What are the applications of Application
L-Thyroxine Sodium Salt Pentahydrate is a thyroid hormone
Hazard
A reproductive hazard.
Biochem/physiol Actions
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.
Purification Methods
Crystallise the sodium salt from absolute EtOH and dry it for 8hours at 30o/1mm. [Canepa Acta Cryst 4 283 1951, Beilstein 14 II 378, 14 III 1566, 14 IV 2374.]
Properties of Sodium levothyroxine pentahydrate
| Melting point: | 207-210 (dec.)(lit.) |
| alpha | [α]D20 +15～+19° |
| Density | 2.381 |
| storage temp. | 2-8°C |
| solubility | cell culture medium: 0.1 mg/mL |
| form | powder |
| color | White to Yellow to Orange |
| BRN | 5721845 |
| CAS DataBase Reference | 6106-07-6(CAS DataBase Reference) |
Safety information for Sodium levothyroxine pentahydrate
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H372:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P314:Get medical advice/attention if you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Sodium levothyroxine pentahydrate
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