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HomeProduct name listrotundine

rotundine

  • CAS NO.:483-14-7
  • Empirical Formula: C21H25NO4
  • Molecular Weight: 355.43
  • MDL number: MFCD03265591
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
rotundine  Structural

What is rotundine ?

Chemical properties

Off-White Solid

The Uses of rotundine

Rotundine is an analgesic drug found in Chinese herbal medicine, used to treat heart disease and liver damage.

What are the applications of Application

L-Tetrahydropalmatine is An alkaloid that depletes neurotransmitters

Definition

ChEBI: A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.

Biological Activity

levo-tetrahydropalmatine (l-thp) is an active herbal constituent of preparations containing plant species of the genera stephania and corydalis. in china, it has been approved and used for a number of clinical indications under the drug name rotundine.

in vitro

in contrast to other thpb derivatives, l-thp is an antagonist at both of d1 and d2 receptors. the ki values for l-thp at d1 and d2 dopamine receptors are approximately 124 nm (d1) and 388 nm (d2), while the ic50 values are 166 nm and 1.4 μm for d1 and d2, respectively. the relatively high affinity of l-thp at d1 vs. d2 receptors, distinguishes it from other available dopamine receptor antagonist drugs (e.g., haloperidol) [1].

in vivo

it has been found that l-thp produces dose-dependent reductions in locomotor activity and operant responding for non-drug reinforcers in rats [1].

References

[1] wang jb, mantsch jr. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. future med chem. 2012 feb;4(2):177-86.

Properties of rotundine

Melting point: 141-143°C
storage temp.  Sealed in dry,2-8°C
solubility  insoluble in H2O; ≥16 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic
pka 6.53±0.20(Predicted)
Boiling point: 482.9±45.0 °C(Predicted)
Density  1.23±0.1 g/cm3(Predicted)
form  powder to crystal
color  White to Light yellow
λmax 280nm(lit.)
CAS DataBase Reference 483-14-7

Safety information for rotundine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H227:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for rotundine

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