SNC 80

Description

SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (K_i = 0.18 nM, IC₅₀ = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC₅₀ = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo.

Chemical properties

Crystalline Solid

The Uses of SNC 80

A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors

The Uses of SNC 80

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

What are the applications of Application

SNC 80 is a highly selective and potent non-peptide δ-opioid receptor (DOR) agonist

Definition

ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.

Biological Activity

A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors.

Biochem/physiol Actions

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4

storage

Store at RT