Skepinone-L
- CAS NO.:1221485-83-1
- Empirical Formula: C24H21F2NO4
- Molecular Weight: 425.42
- MDL number: MFCD22572738
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Skepinone-L?
Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.
The Uses of Skepinone-L
Skepinone-L is a potent and highly selective inhibitor of p38 MAP kinase which impairs platelet activation and thrombus formation.
References
[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.
Properties of Skepinone-L
Melting point: | 130-134°C |
Boiling point: | 629.0±55.0 °C(Predicted) |
Density | 1.384±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C(protect from light) |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 13.49±0.20(Predicted) |
color | Light Yellow to Yellow |
Safety information for Skepinone-L
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Skepinone-L
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