SITS

Synonym(s):Disodium 4-acetamido-4′-isothiocyanato-stilben-2,2′-disulfonate;SITS

CAS NO.：51023-76-8
Empirical Formula: C17H12N2Na2O7S3
Molecular Weight: 498.46
MDL number: MFCD00007485
EINECS: 256-919-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:20

What is SITS?

Chemical properties

Light Yellow Solid

The Uses of SITS

A fluorescent label for the specific and reversible labelling of the outer components of the plasma membrane. The reagent reacts with a fixed number of sites on the surface of cells concerned with anion permeation; does not pass through the osmotic barrier of the membrane; reacts under physiological conditions of temperature, pH and tonicity; and is detectable in small amounts. SEE ALSO NOTES FOR DIDS (CAT#D460600). Fluorescence: max. Abs. l = 336nm, max. Em. l = 436 nm.

The Uses of SITS

Fluorescent marker for membranes; inhibits anion permeability of membranes. Also inactivates Na,K-ATPase, by covalent modification of a specific Lys residue.

Properties of SITS

Melting point:	>300°C (dec.)
storage temp.	-20°C
solubility	Soluble in water, methanol, dimethyl sulfoxide
form	powder
color	Yellow or tan-yellow
λmax	336 nm
BRN	9177451
Stability:	Temperature sensitive - recommended storage at -20oC
Biological Applications	Chloride channel blockers; anion transport inhibitors; treating cancer,glaucoma,heart diseases,viral diseases
CAS DataBase Reference	51023-76-8(CAS DataBase Reference)
EPA Substance Registry System	Benzenesulfonic acid, 5-(acetylamino)-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]-, disodium salt (51023-76-8)

Safety information for SITS

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.