SITS
Synonym(s):Disodium 4-acetamido-4′-isothiocyanato-stilben-2,2′-disulfonate;SITS
- CAS NO.：51023-76-8
- Empirical Formula: C17H12N2Na2O7S3
- Molecular Weight: 498.46
- MDL number: MFCD00007485
- EINECS: 256-919-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is SITS?
Chemical properties
Light Yellow Solid
The Uses of SITS
A fluorescent label for the specific and reversible labelling of the outer components of the plasma membrane. The reagent reacts with a fixed number of sites on the surface of cells concerned with anion permeation; does not pass through the osmotic barrier of the membrane; reacts under physiological conditions of temperature, pH and tonicity; and is detectable in small amounts. SEE ALSO NOTES FOR DIDS (CAT#D460600). Fluorescence: max. Abs. l = 336nm, max. Em. l = 436 nm.
The Uses of SITS
Fluorescent marker for membranes; inhibits anion permeability of membranes. Also inactivates Na,K-ATPase, by covalent modification of a specific Lys residue.
Properties of SITS
| Melting point: | >300°C (dec.) |
| storage temp. | -20°C |
| solubility | Soluble in water, methanol, dimethyl
sulfoxide |
| form | powder |
| color | Yellow or tan-yellow |
| λmax | 336 nm |
| BRN | 9177451 |
| Stability: | Temperature sensitive - recommended storage at -20oC |
| Biological Applications | Chloride channel blockers; anion transport inhibitors; treating cancer,glaucoma,heart diseases,viral diseases |
| CAS DataBase Reference | 51023-76-8(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenesulfonic acid, 5-(acetylamino)-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]-, disodium salt (51023-76-8) |
Safety information for SITS
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SITS
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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